Publications

Orepic P, Truccolo W, Halgren E, Cash SS, Giraud AL, Proix T (2026) Top-down semantic predictions align phonetic neuronal dynamics in human superior temporal gyrus. Nature Communications, accepted

Hahn NV, Stein E, BrainGate Consortium, Donoghue JP, Simeral JD, Hochberg LR, Willett FR (2026) Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participants. Nature Medicine, accepted

Wang F, Xing D, Borton DA, Truccolo W (2026) Motor cortex oscillatory LFP transients during locomotion in nonhuman primates. Proceedings IEEE Eng Med Biol Soc (EMBC), Toronto.

Moosavi SA, Feldman JS, Truccolo W (2025) Controllability of nonlinear epileptic-seizure spreading dynamics in large-scale subject-specific brain networks. Nature Scientific Reports 15(1): 6467

Ho ECY, Newton A, Urdapilleta, Dura-Bernal S, Truccolo W (2025) Downmodulation of potassium conductances induces epileptic seizures in cortical network models via multiple synergistic factors. J Neurosci 45(13): e1909232025

Liu Z, Wang M, Pan X, Yang Y, Truccolo W, Liu Q (2025) Personalized optimization of pediatric HD-tDCS for dose consistency and target engagement. arXiv: 2512.01406v1

Mohammadi N, Truccolo* W, Cash SS, Giraud AL, Proix* T (2024) From spiking neuronal networks to interpretable dynamics: a diffusion-approximation framework. bioRxiv, 2024.12. 17.628339 *Senior authors

Orepic P, Truccolo W, Cash SS, Giraud AL, Proix T (2024) Neural manifolds carry reactivation of phonetic representations during semantic processing. bioRxiv doi:2023.10.30.564638

Moosavi SA, Truccolo W (2023) Criticality in probabilistic models of spreading dynamics in brain networks: epileptic seizures. PLoS Computational Biology 19(2): e1010852. https://doi.org/10.1371/journal.pcbi.1010852

Moosavi SA, Truccolo W (2023) Linear feedback control of spreading dynamics in stochastic nonlinear network models: epileptic seizures. Proceedings IEEE EMBS Neural Engineering: 1-6. doi:10.1109/ner52421.2023.10123896

Xing D, Truccolo W, Borton DA. (2022) Emergence of distinct neural subspaces in motor cortical dynamics during volitional adjustments of ongoing locomotion. J Neurosci 42(49): 9142-9157. Highlighted in the journal’s Featured Research.

Moosavi SA, Jirsa VK, Truccolo W (2022) Critical dynamics in the spread of focal epileptic seizures: network connectivity, neural excitability and phase transitions. PLoS One 17 (8), e0272902.

Cu H, Lynch L, Huang K, Truccolo W, Nurmikko A (2022) Grasp-squeeze adaptation to changes in object compliance leads to dynamic beta-band communication between primary somatosensory and motor cortices. Nature Scientific Reports 12: 6776.

Truccolo W (2022) Population encoding/decoding. In Encyclopedia of Computational Neuroscience (Eds. Jaeger D and Jung R). Second Edition. Springer, New York.

Proix T, Truccolo W, Leguia MG, Tcheng TK, King-Stephens D, Rao VR, Baud MO (2021) Forecasting seizure risk in adults with focal epilepsy: a development and validation study. The Lancet Neurology 20(2): 127 – 135.

Zelmann R, Paulk AC, Basu I, Sarma A, Yousefi A, Crocker BA, Eskandar E, Williams Z, Cosgrove GR, Weisholtz DS, Dougherty DD, Truccolo W, Widge AS, Cash SS (2020) CLoSES: a platform for closed-loop intracranial stimulation in humans. NeuroImage 223: 117314.

Krempp C, Paulk AC, Truccolo W, Cash SS, Zelmann R (2020) Effect of closed-loop direct electrical stimulation during sleep spindles in humans. Proceedings IEEE Eng Med Biol Soc (EMBC): 3586 – 3589.

Park YS, Cosgrove GR, Madsen JR, Eskandar EN, Hochberg LR, Cash SS, Truccolo W (2020) Early detection of human epileptic seizures based on intracortical microelectrode array signals. IEEE Trans Biom Eng 67(3): 817 – 831.

Heelan C, Lee J, O’Shea R, Brandman DM, Truccolo W, Nurmikko AV (2019) Decoding speech from spike-based neural population recordings in secondary auditory cortex of non-human primates. Nature Communications Biol 2: 466. www.nature.com/commsbio: https://doi.org/10.1038/s42003-019-0707-9

Proix T, Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W (2019) Intracortical neural activity distal to seizure onset areas predicts human focal seizures. PLoS ONE 14 (7).

D Xing, M Aghagolzadeh, W Truccolo, D Borton (2019) Low-dimensional motor cortex dynamics preserve kinematics information during unconstrained locomotion in nonhuman primates. Frontiers in Neuroscience 13: 1 – 10.

Todorov D, Truccolo W (2019) Stability of stochastic finite-size spiking-neuron networks: comparing mean-field, 1-loop correction and quasi-renewal approximations. Proceedings IEEE Eng Med Biol Soc (EMBC): 4380 – 4386. Errata

Saha D, Truccolo W (2019) Stochastic point process models for multi-compartment dendritic-tree input-output transformations in spiking neurons. Proceedings IEEE Eng Med Biol Soc (EMBC): 4395 – 4399.

Saha D, Proix T, Truccolo W (2019) Ongoing intracortical neural activity predicts upcoming interictal epileptiform discharges in human epilepsy. Proceedings IEEE Eng Med Biol Soc (EMBC): 2386 – 2391.

Rapela J, Proix T, Todorov D, Truccolo W (2019) Uncovering low-dimensional structure in high-dimensional representations of long-term recordings in people with epilepsy. Proceedings IEEE Eng Med Biol Soc (EMBC): 2246 – 2251.

Zsom A, LaFrance Jr WC, Blum AS, Li P, Wahed LA, Shaikh MA, Sharma G, Ranieri R, Zhang L, Tsekhan S, Hamid T, Levin J, Truccolo W (2019) Ictal autonomic activity recorded via wearable-sensors plus machine learning can discriminate epileptic and psychogenic nonepileptic seizures. Proceedings IEEE Eng Med Biol Soc (EMBC): 3502 – 3506.

Proix T, Jirsa VK, Bartolomei F, Guye M, Truccolo* W (2018) Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy. Nature Communications 9:1088,doi: 10.1038/s41467-018-02973-y. View article (+SI) .

Pesaran B, Vinck M, Einevoll GT, Sirota A, Fries P, Siegel M, Truccolo W, Schroeder CE, Srinivasan R (2018) Investigating large-scale brain dynamics using field potential recordings: analysis and interpretation. Nature Neuroscience, 21: 903 – 919. (Invited primer)

Rule ME, Vargas-Irwin C, Donoghue JP, Truccolo W (2018) Phase reorganization leads to transient β-LFP spatial-wave patterns in

motor cortex during steady-state movement preparation. J Neurophys, 119: 2212 – 2228.

Heelan C, Nurmikko AV, Truccolo W (2018) FPGA implementation of deep-learning recurrent neural networks with sub-millisecond real-time latency for BCI-decoding of large-scale neural sensors (10^4 nodes), Conf Proc IEEE Eng Med Biol Soc. 2018: 1070 – 1073.

Wang Y, Truccolo W, Borton DA (2018) Decoding hindlimb kinematics from primate motor cortex using long short-term memory recurrent neural networks. Conf Proc IEEE Eng Med Biol Soc. 2018: 1944 – 1947.

Gerhard F, Deger M, Truccolo W (2017) On the stability and dynamics of stochastic spiking neuron models: nonlinear Hawkes process and point process GLMs. PLoS Comput Biol 13(2): e1005390. doi:10.1371/journal.pcbi.1005390. View article

Rule ME, Vargas-Irwin C, Donoghue JP, Truccolo W (2017) Dissociation between sustained single-neuron spiking and transient β-LFP oscillations in primate motor cortex. J Neurophysiol, 117(4): 1524 – 543. doi: 10.1152/jn.00651.2016.

Heitmann S, Rule M, Truccolo W, Ermentrout B (2017) Optogenetic stimulation shifts the excitability of cerebral cortex from Type I to Type II: oscillation onset and wave propagation. PLoS Computational Biology 13(1): e1005349. doi:10.1371/journal.pcbi.1005349. View article

Martinet LE, Fiddyment G, Madsen J, Eskandar E, Truccolo W, Eden U, Cash SS, Kramer MA (2017) Human seizures couple across spatial scales through traveling wave dynamics. Nature Communications, 8:14896, 1 – 13, DOI: 10.1038/ncomms14896. View article

Truccolo W (2016) From point process observations to collective neural dynamics: nonlinear Hawkes process GLMs, low-dimensional dynamics and coarse graining. J Physiol, Paris, advance online. View article

Ho ECY, Truccolo W (2016) Interaction between synaptic inhibition and glial-potassium dynamics leads to diverse seizure transition modes in biophysical models of human focal seizures. J Computational Neuroscience, 41(2): 225 – 244. View article

Sarma AA, Crocker B, Cash SS, Truccolo W (2016) A modular, closed-loop platform for intracranial stimulation in people with neurological disorders. Int IEEE EMBS Conf Neural Engineering, 6139 – 6142.

Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W (2016) Predicting seizures from local field potentials recorded via intracortical microelectrode arrays. Int IEEE EMBS Conf Neural Engineering, 6353 – 6356.

Aghagolzadeh M, Truccolo W (2016) Inference and decoding of motor cortex low-dimensional dynamics with latent state-space models. IEEE Transactions Neural Systems Rehabilitation Engineering, 24(2): 272 – 282.

Wagner F, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash SS, Truccolo W (2015) Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures. NeuroImage, 122: 114 – 130.

Truccolo W (2015) Population Encoding/Decoding. In Encyclopedia of Computational Neuroscience (Eds. Jaeger D and Jung R). Springer, New York.

Wagner FB, Truccolo W, Wang J, Nurmikko AN (2015) Spatiotemporal dynamics of optogenetically-induced and spontaneous seizure transitions in primary generalized epilepsy. J Neurophysiology 113(7): 2321 – 2341.

Milekovic T, Truccolo W, Grün S, Riehle A, Brochier T (2015) Local field potentials in primate motor cortex encode grasp kinetic parameters. NeuroImage, 114: 338 – 335.

Lu Y, Truccolo W, Wagner FBP, Vargas-Irwin CE, Ozden I, Zimmermann JB, May T, Agha N, Wang J, Nurmikko AV (2015) Optogenetically-induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex. J Neurophysiology 113(10): 3574 – 3587.

Rule ME, Vargas-Irwin CE, Donoghue JP, Truccolo W (2015) Contribution of LFP dynamics to single-neuron spiking variability in motor cortex during movement execution. Frontiers in Systems Neuroscience, 9(89): 10.3389/fnsys.2015.00089.

Harrison MT, Amarasingham A, Truccolo W (2015) Spatiotemporal conditional inference and hypothesis tests for neural ensemble spiking precision. Neural Computation, 27(1): 104 – 150.

Truccolo* W, Ahmed OJ, Harrison MT, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash* SS (2014) Neuronal ensemble synchrony during human focal seizures. J Neuroscience, 34(30): 9927 – 9944.

* Senior authors

Menzer D, Rao NG, Bondy A, Truccolo W, Donoghue JP (2014) Population interactions between parietal and primary motor cortices during reach. J Neurophysiology: 112(11): 2959 – 2984.

Aghagolzadeh M, Truccolo W (2014) Latent state-space models for neural decoding. Int IEEE EMBS Conf Neural Engineering, 3033 – 3036.

Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W (2014) Early detection of human focal seizures based on cortical multiunit activity. Int IEEE EMBS Conf Neural Engineering, 5796 – 5799.

Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W (2013) Early detection of human epileptic seizures based on intracortical local field potentials. Int IEEE EMBS Conf Neural Eng.: 323 – 326.

Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W (2013) Adaptive parametric spectral estimation with Kalman smoothing for online early seizure detection. Int IEEE EMBS Conf Neural Eng.: 1410 – 1413.

Kramer MA, Truccolo W, Eden UT, Lepage KQ, Hochberg LR, Eskandar EN, Madsen JR, Lee JW, Maheshwari A, Halgren E, Chu CJ, Cash SS (2012) Human seizures self-terminate across spatial scales via a critical transition. Proceedings of the National Academy of Science, 109(51): 21116–21121.

Bansal AK, Truccolo W, Vargas-Irwin CE, Donoghue JP (2012) Decoding 3-D reach and grasp from hybrid signals in motor and premotor cortices: spikes, multiunit activity and local field potentials. J Neurophysiology 107: 1337 – 1355.

Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. (2011) Single-neuron dynamics in human focal epilepsy. Nature Neuroscience, 14(5): 635 - 641.

Bansal AK, Vargas-Irwin CE, Truccolo W, Donoghue JP (2011) Relationships among low-frequency local field potentials, spiking activity, and 3-D reach and grasp kinematics in primary motor and ventral premotor cortices. J Neurophysiology 105: 1603 – 1619.

Malik W, Truccolo W, Brown EN, Hochberg LR (2011) Efficient decoding with steady-state kalman filter in neural interface systems. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 19(1): 25-34.

Truccolo W, Hochberg LR, Donoghue JP (2010) Collective dynamics in human and monkey sensorimotor cortex: Predicting single neuron spikes. Nature Neuroscience, 13(1): 105-111.

Truccolo W (2010) Stochastic models for multivariate neural point processes: Collective dynamics and neural decoding. In Analysis of parallel spike trains (Eds. Grün S and Rotter S). Springer, New York.

Zhuang J, Truccolo* W, Vargas-Irwin C, Donoghue JP (2010) Decoding 3-D reach and grasp kinematics from high-frequency local field potentials in primate primary motor cortex. IEEE Transactions on Biomedical Engineering, 57(7): 1774-1784. [*Corresponding author.]

Zhuang J, Truccolo W, Vargas-Irwin C, Donoghue JP (2010) Reconstructing grasping motions from high-frequency local field potentials in primary motor cortex. IEEE-EMBS Proceedings: 4347-4350.

Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle W, Madsen JR, Schomer D, Mehta A, Brown EN, Hochberg LR, Ulbert I, Halgren E, Cash SS (2010) Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain, 133: 1668-1681.

Truccolo W, Friehs GM, Donoghue JP, Hochberg LR (2008) Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia. Journal of Neuroscience, 28 (5): 1163-1178.

Nalatore H, Truccolo W, Rangarajan G (2007) Fast robust pattern classification algorithms for real time neuro-motor prosthesis applications. Journal of the Indian Institute of Science, 87 (4): 497-509.

Truccolo W and Donoghue JP (2007) Non-parametric modeling of neural point processes via stochastic gradient boosting regression. Neural Computation, 19(3): 672-705.

Chen Y, Bressler SL, Knuth KH, Truccolo W, Ding M (2006) Stochastic modeling of neurobiological time series: Power, coherence, granger causality, and separation of evoked responses from ongoing activity. Special Edition on Stochastic Dynamics of Neural and Genetic Networks, Andre Longtin (Ed.). Chaos, 16, 026113 1-8.

Knuth KH, Shah A, Truccolo W, Ding M, Bressler SL, Schroeder CE (2006) Differentially variable component analysis (dVCA): Identifying multiple evoked components using trial-to-trial variability. J Neurophysiology, 95, 3257-3276.

Truccolo W, Eden UT, Fellows MR, Donoghue JP, Brown EN (2005) A point process framework for relating neural spiking activity to spiking history, neural ensemble and extrinsic covariate effects. J Neurophysiology, 93, 1074-1089.

Eden UT, Truccolo W, Fellows MR, Donoghue JP, Brown EN (2004) Reconstruction of hand movement trajectories from a dynamic ensemble of spiking motor cortical neurons. Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA.

Albo Z, Viana di Prisco G, Chen Y, Rangarajan G, Truccolo W, Feng J, Vertes RP, Ding M (2004) Is partial coherence a viable technique for identifying generators of neural oscillations? Biological Cybernetics, 90, 318-326.

Truccolo W, Knuth KH, Shah A, Schroeder C, Bressler SL, Ding M (2003). Estimation of single-trial multi-component ERPs: differentially variable component analysis (dVCA). Biological Cybernetics, 89, 426-438.

Truccolo WA, Rangarajan G, Chen Y, Ding M (2003) Analyzing stability of equilibrium points in neural networks: A general approach. Neural Networks, 16(10), 1453-1460.

Sanes JN and Truccolo W (2003). Motor "Binding": do Functional Assemblies in Primary Motor Cortex have a Role? Neuron, 38 (1): 3-5.

Truccolo WA., Ding M, Knuth KH, Nakamura R, Bressler SL (2002) Trial-to-trial variability of cortical evoked responses: Implications for the analysis of functional connectivity. Clinical Neurophysiology, 113, 206–226.

Truccolo WA, Knuth KH, Bressler SL, Ding M (2002) Bayesian analysis of single trial cortical event-related components. In Robert L. Fry (Ed.), Maximum Entropy and Bayesian Methods in Science and Engineering. AIP Conference Proceedings, 617, 64-73. Melville, NY: American Institute of Physics.

Liang H, Bressler SL, Ding M, Truccolo WA, Nakamura R (2002) Synchronized activity in prefrontal cortex during anticipation of visuomotor processing. Neuroreport, 13(16), 2011-2015.

Truccolo WA, Dong DW (2001) Dynamic temporal decorrelation: Information theoretic and biophysical model of the functional role of the lateral geniculate nucleus (LGN). Neurocomputing, 38-40, 993-1001.

Truccolo WA, Ding M, Bressler SL (2001) Variability and interdependence of local field potentials: Effects of gain modulation and nonstationarity. Neurocomputing, 38-40, 983-992.

Kaminski M, Ding M, Truccolo WA, Bressler SL (2001) Evaluating causal relations in neural systems: Granger causality, directed transfer function (DTF) and statistical assessment of significance. Biological Cybernetics, 85, 145-157.

Knuth KH, Truccolo WA, Bressler SL, Ding M (2001) Separation of multiple evoked responses using differential amplitude and latency variability. In Sejnowski, T.J. (Ed.), Proceedings of the 3rd International Conference on Independent Component Analysis and Blind Signal Separation, San Diego, California, USA.

Truccolo WA, Ding M, Bressler SL (2000) Stability constraints for oscillatory neural networks. Neurocomputing, 32-33, 585-589.

Truccolo W, Dong DW (2000) Dynamic temporal decorrelation: Information theoretic and biophysical model of the functional role of the lateral geniculate nucleus (LGN). Investigative Ophthalmology & Visual Science, 41 (4): 259B259, Suppl. S MAR 15 2000.

Truccolo WA, Ding M, Bressler SL (2000) Dynamical analysis of an oscillatory cortical neural network. In Amari et al. (Eds). Neural Networks. IJCNN 2000, Proceedings of the IEEE-INNS-ENNS International Joint Conference, Volume: 6, 24-27, pp. 434 – 439.